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Symbol
Name
ID

Tyk2
tyrosine kinase 2
MGI:1929470

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Increased circulating IgE level
Disease(s) Associated with TYK2	Increased circulating IgE level
immunodeficiency 35

Mouse Phenotypes

enlarged thymus

enlarged spleen

abnormal common myeloid progenitor cell morphology

abnormal T cell differentiation

thrombocytopenia

decreased plasmacytoid dendritic cell number

decreased IgG1 level

decreased IgG2a level

decreased IgG level

abnormal T cell physiology

abnormal T-helper 1 physiology

decreased macrophage nitric oxide production

abnormal splenocyte physiology

Availability

Mouse Genotype

Tyk2^E775K/Tyk2^E775K

Tyk2^tm1Biat/Tyk2^tm1Biat

Tyk2^tm1Shmd/Tyk2^tm1Shmd

Tyk2^{tm2b(EUCOMM)Hmgu}/Tyk2^{tm2b(EUCOMM)Hmgu}

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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